Welcome to the Tegnér-Björkegren group
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Experimental and Computational Systems Medicine in practice: Since 2002 we have designed and fine-tuned a patient-driven systembiological pipeline to uncover diagnostic markers (SNPs, transcripts, proteins) and molecular mechanisms (networks) governing the development of atherosclerosis. We integrate Clinical Practice, Molecular Biology, Whole-Genome Technologies and Computational Mathematics and our mission is to bring the results to the clinic and the associated research technologies to the community. Our work is carried out at our Interdisciplinary Laboratory for Computational Medicine at GV belonging to Center for Molecular Medicine at Karolinska Institute. We are always keen on developing creative, bright, self-motivated and overachieving individuals into multi-lingual researchers. See Jobs for current opportunites and a description of our research environment.
Scientific services: Upcoming events include serving in the program committe for International Conference on Systems Biology 2008 and organizing an ESF sponsored exploratory workshop om modeling complex diseases (Barcelona, Spain, September 2008). To support the international development medical systems biology Tegnér serve as associate editor for BMC Systems Biology, BMC Research Notes and on the editorial board for IET Systems Biology.
Local community building: We have recently launched the "Seminars in Systems Medicine" [seminars]. Previously we organized and designed the highly popular PhD course on Systems biology - From models organisms to complex diseases. The external PhD course page (as of nov 2006) and our local resource page on computational medicine contains several links to tools and papers.
Scientific output: The CompMed team has published 65 papers since 2002. We have been generously supported by numerous external grants (VR, FP6, FP7, SSF among others).
10 Selected Publications:
[Paper - 61] Transcriptional Profiling Uncovers a Network of Cholesterol-Responsive Atherosclerosis Target Genes PLoS Genetics [To appear]
[Paper - 56] Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia. Proceedings of National Academy of Science Aug, 2007 [pdf] [Supp1] [Supp2]
[Paper - 49] Consistent feature selection for pattern recognition in polynomial time, Journal of Machine Learning Research, 8 (March): 589-612, 2007 [pdf]
[Paper - 48] Detecting Multivariate Differentially Expressed Genes, BMC Bioinformatics, 8 :150 doi 10.1186/1471-2105-8-150 2007 [pdf] [Supp1] [Supp2] [Supp3]
[Paper - 43] Perturbations to uncover gene networks. Trends in Genetics,Jan;23(1):34-41, 2007 [pdf]
[Paper - 28] The transcriptional landscape of the mammalian genome, Science. Sep 2;309 (5740):1559-63, 2005 [pdf]
[Paper - 16] Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. Proceedings of National Academy of Science101:1368-1373, 2004 [pdf]
[Paper -14] Systembiology is taking off. Genome Research. Nov;13(11):2377-80. 2003 [pdf here]
[Paper - 9] Reverse engineering gene networks -- integrating genetic perturbations with dynamical modeling. Proceedings of National Academy of Science. 100, 5944-5949, 2003 [pdf]
[Paper - 6] Reverse engineering gene networks - singular value decomposition and robust regression. Proceedings of National Academy of Science, 99: 6163-6168. 2002 [pdf]